Precision BioSciences, Inc
Precision BioSciences is a U.S.-based clinical-stage gene editing company built around its proprietary ARCUS genome editing platform. The company develops in vivo therapies for genetic and infectious diseases and also licenses ARCUS-related intellectual property to collaborators and other biotechnology companies.
Fiscal year 2025 · change from previous year
Development 2020–2025
Business
Share of revenueDevelopment of proprietary genome editing tools and therapeutic candidates for human disease.
Upfront payments, milestones, and royalties from partners using ARCUS-related IP.
Customers
Precision BioSciences sells primarily to pharmaceutical and biotechnology partners through licensing and collaboration agreements, while its internal programs are aimed at future patients with genetic or infectious diseases. Its commercial counterparties are research-driven companies that need access to genome-editing IP, preclinical know-how, or therapeutic development rights. If approved, future products would be used by hospitals, specialists, and treatment centers rather than sold directly to consumers.
License ARCUS IP or partner on preclinical programs in exchange for upfront fees, milestones, and royalties.
Patients with genetic or infectious diseases who would receive approved ARCUS-based therapies.
Companies and institutions that use ARCUS in discovery, preclinical, or translational work.
Strategy
The company’s strategy is to advance ARCUS-based in vivo therapies while using partnerships and licensing to monetize its platform before full product commercialization. It also seeks to expand its intellectual property portfolio and manufacturing know-how so it can support future clinical and commercial development. These priorities are intended to preserve optionality across both internal drug development and external licensing.
Internal programs are the main path to long-term value creation and future product revenue.
Partner deals can generate non-product revenue and external validation of ARCUS technology.
Genome editing is highly IP-intensive and requires strong preclinical and manufacturing execution.
Geography
Precision BioSciences is headquartered in the United States and conducts its research, development, and corporate activities from there. Its collaboration and licensing model can reach global partners, but the company’s operating footprint is centered on U.S.-based scientific and regulatory infrastructure. Because its programs are pre-commercial, geography matters mainly through where trials, partners, and regulatory approvals are pursued.
Risks
Precision BioSciences faces the typical risks of a clinical-stage gene editing company: uncertain clinical outcomes, regulatory approval risk, and heavy dependence on intellectual property protection. Its business also depends on third-party collaborators, contract research and manufacturing providers, and future access to capital, which can all affect timing and execution. As a pre-commercial company, it is also exposed to cybersecurity, patent, and biosimilar competition risks if any products are approved.
- Clinical development failureImpact: HighLikelihood: High
Therapeutic candidates are still in development and may not show safety or efficacy.
Exposure: In vivo gene editing programs
- Financing riskImpact: HighLikelihood: High
The company has not generated product sales and relies on external capital to fund R&D.
Exposure - Regulatory approval riskImpact: HighLikelihood: Medium
Gene editing products face stringent FDA and foreign review, with possible restrictions or denial.
Exposure: Future BLA or foreign marketing applications
- Intellectual property and license riskImpact: HighLikelihood: Medium
The business depends on patents and license agreements that can expire or be challenged.
Exposure: ARCUS platform and Cellectis-related license terms
- Partner concentration and collaboration riskImpact: MediumLikelihood: High
A meaningful part of revenue comes from collaboration accounting and partner milestones.
Exposure - Cybersecurity and third-party execution riskImpact: MediumLikelihood: Low
R&D, manufacturing, and collaborator data flows depend on external systems and vendors.
Exposure
Accounting
Judgemental itemsRevenue depends on performance obligations, deferred revenue release, and milestone events.
Impact: Can cause large fluctuations unrelated to current-period cash receipts
Prior upfront payments are recognized over time or at contract completion.
Impact: Major driver of year-to-year revenue variability
A meaningful non-cash expense for a small, research-intensive biotech company.
Impact: Affects operating loss and comparability across periods
The company uses leased facilities and third-party research/manufacturing services.
Impact: Affects balance sheet liabilities and operating expense timing
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Last updated: 24/09/2026